Endothelin-2 (49-69), human

CAS No. 123562-20-9

Endothelin-2 (49-69), human ( Endothelin-2, human; Endothelin-2 (49-69), human; Endothelin-2 (human, canine) )

Catalog No. M29577 CAS No. 123562-20-9

Endothelin-2, human is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Endothelin-2 (49-69), human
  • Note
    Research use only, not for human use.
  • Brief Description
    Endothelin-2, human is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.
  • Description
    Endothelin-2, human is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.(In Vitro):At nanomolar concentrations, Endothelin-2 exhibits a strong and long-lasting vasoconstrictor activity characteristic of endothelin (EC50=0.52 nM). Endothelin-2 is a chemoattractant for macrophages and THP-1 monocytic cells, but not for freshly isolated monocytes. The chemotactic response to Endothelin-2 shows a typical bell-shaped response curve. Experiments with endothelin receptor antagonists shows that migration to Endothelin-2 is mediated via the ET-RB receptor. Endothelin-2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia.(In Vivo):Rats For the assay of pressor activity, male Wistar rats weighing 300-350 g are anesthetized with urethane (1 g/kg i.p.) and pretreated with atropine (0.25 mg/kg i.v.), propranolol (1 mg/kg i.v.), and bunazocine (1 mg/kg i.v.). Additional maintenance doses (one-half of the initial doses) of the autonomic blockades are administered every 3-4 hr.
  • Synonyms
    Endothelin-2, human; Endothelin-2 (49-69), human; Endothelin-2 (human, canine)
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    123562-20-9
  • Formula Weight
    2551.0
  • Molecular Formula
    C115H164N26O32S4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(N[C@@H](CO)C(N[C@@H](CS)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CS)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CS)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC6=CNC7=CC=CC=C67)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CS)N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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